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Author

Yunchen Xia

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#gene editing Open access Oct 2026

The effects of DNA repair factor-Cas9 fusions on homing gene drive performance

CRISPR-based homing gene drives achieve super-Mendelian inheritance by converting wild-type alleles into drive alleles through homology-directed repair (HDR). However, competing end-joining repair can generate resistance alleles that limit drive spread. Although fusing Cas9 to DNA repair-associated proteins has improve...

Ying Wu, Xue-Jiao Xu, Nan Liang et al. · 0 citations
Open access Jul 2026

Finding the perfect promoter for Cas9 in homing gene drives using single cell transcriptome data

It is indicated that higher drive conversion is associated with elevated expression of the promoter-associated gene in reproductive cells, but embryo resistance allele formation correlates with excessive female germline expression, and optimal drive performance requires restricting Cas9 expression to a tight quantitati...

Ying Wu, Yunchen Xia, Ziyin Yao et al. · 0 citations

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