Author

Yuan Zou

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Open access Sep 2026

Splicing suppression alters the STING transcription start site to attenuate antiviral innate immunity.

The cGAS (cyclic GMP-AMP synthase)-STING (Stimulator of interferon genes) pathway plays a central role in antiviral innate immunity in vertebrates. Recent studies have shown that invertebrates possess a related cGLR (cGAS-like receptor)-STING pathway. However, due to the lack of direct evidence demonstrating viral evas...

Jia Xu, Qiu-Chang Liao, Jia-Yin Wang et al. · Proceedings of the National... · 0 citations

#gene editing Sep 2026

Targeting DOPA decarboxylase disrupts immune-metabolic coordination and renders Spodoptera frugiperda susceptible to bacterial infection.

DOPA decarboxylase (DDC) is a key enzyme that connects melanin production and innate immunity in insects, yet its regulatory network in major lepidopteran pests remains poorly understood. We combined CRISPR/Cas9 gene editing with multi-omics analysis to explore DDC's role in immune responses in the invasive pest Spodop...

Ze-Yuan Zhang, Shang-Huan Huang, Shen-Lei Li et al. · Insect Science · 0 citations