Towards Structured Mechanistic Reasoning in Single-cell Prediction
Yun-Hui Jang, Kaist Lu Zhu, Jake Fawkes et al.
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Aug 2026
A Network-Guided Modular Framework for drug response prediction in acute myeloid leukemia.
NGM-AML, a modular model predicting ex vivo drug response from BeatAML2 RNA-seq and sensitivity data, achieves mean Pearson and Spearman correlations of 0.324 and 0.326 across drugs, consistent with known AML survival and drug-resistance mechanisms.
Yu-Rung Wu, Yuan Wang, Wen-Jia Zhao et al.
· Computational biology and ch... · 0 citations