Author

Yu-Ru Huang

2 papers indexed here

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Open access Aug 2026

In vivo genome editing of central nervous system SIV reservoirs in ART-suppressed rhesus macaques

It is demonstrated that intact and potentially replication-competent virus persists in the primate brain under ART and that systemic AAV9-CRISPR can reach and edit proviral DNA in this sanctuary, supporting genome editing as a strategy toward durable remission of CNS reservoirs.

Hong Liu, Shu-Ren Liao, Chen Chen et al. · Molecular Therapy: Nucleic A... · 1 citation

#gene editing Open access Aug 2026

Triple-Target CRISPR Strategy to Block HIV Entry and Replication in Permissive Cells

The combination knockout of CCR5, MOGS, and viral sequences profoundly reduces HIV-1 replication in an ex vivo cellular model, that is, HIV-1-infected peripheral blood mononuclear human cells, thus offering a pathway to launch further preclinical studies.

Z. Safaei, Anna Bellizzi, Hong Liu et al. · Human Gene Therapy · 0 citations