Author

Ying-Jian Wang

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Open access Oct 2026

Integrative single-cell and computational pathology analyses reveal a C11orf24-associated stem-like epithelial population linked to tumor microenvironment remodeling and immune evasion in bladder cancer.

BACKGROUND Cancer stem-like cells drive tumor progression and therapeutic resistance, yet the epithelial stemness hierarchy in bladder cancer (BLCA) remains poorly defined. We aimed to characterize stemness-associated epithelial populations and their clinical significance. METHODS We analyzed single-cell RNA sequenci...

Ying-Jian Wang, Song-Xin Zhang, Xi Luo et al. · Translational Oncology · 0 citations

Open access Sep 2026

Multimodal AI and single-cell transcriptomics integrate to construct a histopathological prognostic model for bladder cancer, revealing the RTN3-glycolysis axis in chemoresistance

The findings establish the RTN3/JAK2/STAT3/glycolytic metabolic reprogramming axis as a critical mechanism of gemcitabine resistance, highlighting RTN3 as a promising therapeutic target for overcoming chemoresistance in bladder cancer.

Shun-Li Yu, Ying-Jian Wang, Da-Peng Feng et al. · Experimental Hematology & On... · 0 citations

Open access Sep 2026

Machine learning and multi-omics clustering to map cellular rewiring and immune evasion in ccRCC

The CMLS translates spatial immune-exclusion dynamics into a quantifiable metric, outperforming tumor mutational burden in predicting ICB benefits, providing a robust tool for patient stratification in ccRCC.

Zhe Wang, Ying-Jian Wang, Jia-Yi Zhang et al. · Human Genomics · 0 citations

Open access Aug 2026

Integrative multi-omics reveals the POSTN+ CAF–APOE+ macrophage axis drives immunosuppression and progression in prostate cancer

An integrated single-cell atlas defines a critical POSTN+ CAF–APOE+ macrophage unit that is associated with a fibrotic and immunosuppressive TME in advanced prostate cancer, and suggested conserved enrichment and adverse prognostic impact of this stromal-immune axis across diverse tumor types, though tissue-specific co...

Yangzhou Liu, Ao-Chu Liu, Xing-Lai Dai et al. · Frontiers in Immunology · 0 citations