Automatic grading of HER2 immunohistochemical whole-slide images based on a multi-scale hierarchical graph neural network
Objective The HER2 immunohistochemical (IHC) score of breast cancer is a critical precursor for determining eligibility for anti-HER2 targeted therapy, as the final HER2 status (positive/negative/low) is determined by IHC results combined with FISH confirmation for equivocal 2 + cases according to ASCO/CAP guidelines....