Aug 2026
Transferable genetic toolsets for nonmodel gut Clostridia enable in vivo reversible control of metabolite production.
This work identifies a panel of strong constitutive promoters that drive robust gene expression across diverse clostridial strains and develops an inducible promoter system that enables precise, tunable gene regulation and facilitates the implementation of CRISPR-Cas gene-deletion systems.
Ting-Ting Li, Xi Chen, Fang Wang et al.
· Nature Biotechnology · 0 citations