Author

Yang Li

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Review Open access Sep 2026

Bispecific antibody-drug conjugates in cancer: therapeutic-window determinants, tumour-immune interactions, and clinical translation

Antibody-drug conjugates (ADCs) have established targeted payload delivery as an important anticancer strategy, but their efficacy remains constrained by antigen heterogeneity, incomplete internalisation, resistance and dose-limiting toxicity. Bispecific antibody-drug conjugates (BsADCs) add a second antigen- or epitop...

Yang Li, Yu Li, Rong-Fong Huang et al. · Frontiers in Immunology · 0 citations

#gene editing Review Open access Sep 2026

Engineering strategies to address immune and delivery barriers in pancreatic ductal adenocarcinoma: a barrier-matched translational framework

This review evaluates oncolytic virotherapy, gene-editing technologies, engineered immune-cell therapies, nanotechnology-enabled delivery systems, and artificial intelligence-assisted precision oncology according to the PDAC barriers they are intended to address and the maturity of the supporting evidence.

Yang Li, Yu Li, Jia Fan et al. · Frontiers in Immunology · 0 citations