Author

Yadi Zhou

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#gene editing Open access Oct 2026

Alzheimer's disease target and drug discovery by leveraging multiomics and electronic health data.

Despite prolific genomic data from individuals with Alzheimer's disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of Europea...

Yuan Hou, Yi-Chen Li, Peng-Yue Zhang et al. · Nature Neuroscience · 0 citations

Open access Aug 2026

Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.

Genetically ablated the deISGylating activity of the SARS-CoV-2-encoded papain-like protease (PLpro) and found that loss of deISGylation boosted innate immune activation, attenuated viral replication, and promoted viral clearance in human cells and mice.

Jun-Ji Zhu, Guan-Qun Liu, Jie-Lin Xu et al. · Immunity · 1 citation