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Oct 2026

A lymph node-targeted nanoplatform reprograms metabolic and immune microenvironments via dual ACSL3/4 inhibition in lymphatic metastatic tumors.

Lymph node metastasis in hepatocellular carcinoma depends heavily on lipid metabolic reprogramming, wherein the acyl-CoA synthetase long-chain family members ACSL3 and ACSL4 act as central survival hubs. However, single-target interventions often fail to curb metastasis due to the inherent metabolic plasticity and flex...

Bai-Xue Fu, Rui Gao, Zhi-Zheng Xie et al. · 0 citations
#artificial intelligence Open access Mar 2026

SCALE: Scalable Conditional Atlas-Level Endpoint Transport for virtual cell perturbation prediction

A conditional transport model that represents cells as unordered sets and predicts treated populations without cell-level matching that enables perturbation-specific prediction from unpaired populations and supports experimental prioritization is presented.

Shui-Zhou Chen, Lang Yu, Xu Lin et al. · 0 citations

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