The effects of DNA repair factor-Cas9 fusions on homing gene drive performance
CRISPR-based homing gene drives achieve super-Mendelian inheritance by converting wild-type alleles into drive alleles through homology-directed repair (HDR). However, competing end-joining repair can generate resistance alleles that limit drive spread. Although fusing Cas9 to DNA repair-associated proteins has improve...
Ying Wu, Xue-Jiao Xu, Nan Liang et al.
· bioRxiv · 0 citations