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Review Oct 2026

Molecular biomarkers for diagnosis, prognosis, precision therapy, and immunotherapy in cholangiocarcinoma, cHCC-CCA, and HCC

This review organizes biomarkers by the treatment decision they are expected to support, which covers curative intent and locoregional risk stratification, molecularly guided systemic therapy, immune-state assessment, dynamic monitoring, resistance reassessment, and translational readiness.

Jing-Guo Sun, Ying-Jie Lu, Lu Chang et al. · 0 citations
Review Oct 2026

Precision toxicity control in checkpoint immunotherapy.

Immune checkpoint inhibitors have changed cancer management. However, immune-related adverse events (irAEs) can disrupt treatment and limit effective combination strategies. The standard of care tends to involve broad immunosuppression, which may compromise antitumor immunity and fail to address the dominant biology of...

Zhen Sun, Xiao-Yi Yang, Wei-Ming Shen et al. · 0 citations

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