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Xu-Feng Qi

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Sep 2026

ALKBH5-Dependent m6A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration.

BACKGROUND N6-methyladenosine (m6A) modification has been linked to various types of physiological and pathological bioprocesses. However, the exact role of m6A mRNA methylation in cardiac aging is largely unknown. Here, we show that ALKBH5 (alpha-ketoglutarate-dependent dioxygenase AlkB homolog 5), an m6A demethylase,...

Kun Liu, Chi-Qian Liang, Hong-Ji Li et al. · 0 citations
#gene editing Open access Aug 2026

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

Findings establish Cas7-11 as a precise and efficient RNA knockdown tool for functional studies in embryonic development and stem cell biology, providing a versatile alternative to DNA-based gene-editing approaches.

Huan Yan, Imtiaz Ul Hassan, Kai Yan et al. · 0 citations

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