To continue our research on developing PPO inhibitors, we replaced the triazinone core of compounds B, G, and H from our previous work with pyrimidinediones, employing a scaffold-hopping strategy to design and synthesize compounds I, J, and K. Compound I18 exhibited potent NtPPO inhibition (Ki = 10.9 nM) and broad-sp...
Wei Zhang, Ke-Shi Luo, Di Li et al.· Journal of Agricultural and...· 0 citations
Protoporphyrinogen oxidase (PPO) is one of the major targets for herbicide discovery. N-Phenylpyrazole derivatives bearing ester, oxime, and isoxazoline moieties were synthesized via isomerization, derivatization and cyclization. Bioassays showed C34 potently inhibited Nicotiana tabacum PPO (NtPPO) (Ki = 15.6 nM), wi...
Jia-Hui Zhang, Wei Zhang, Xian-Ying Tang et al.· Journal of Agricultural and...· 0 citations
The application of herbicides plays a critical role in ensuring food security. However, the long-term overuse of herbicides can lead to a range of adverse effects. Therefore, it is essential to develop innovative and sustainable herbicides. A series of pyridazinone derivatives targeting phytoene desaturase (PDS) were d...
Chao Chen, Yan Li, Wei Zhang et al.· Journal of Agricultural and...· 0 citations
The use of herbicides represents one of the effective weed management strategies. To create high-efficiency, low-risk protoporphyrinogen IX oxidase (PPO)-targeted herbicides, a set of novel N-phenylphthalimides bearing 1,3,4-oxadiazole and acylhydrazide fragments was designed and synthesized. Bioassays revealed that mo...
Wang Geng, Yan Li, Wei Zhang et al.· Journal of Agricultural and...· 0 citations
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a vital target for herbicide development. A series of pyrazole-quinoxaline conjugates were designed and synthesized via scaffold hopping and structural optimization. Bioassays revealed that B9 exhibited potent inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) w...
Li Liu, Mei Zhang, Lingling Wang et al.· Journal of Agricultural and...· 0 citations
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