Author

Xiaoming Tao

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Open access Aug 2026

TMEM176B orchestrates intratumoral hierarchy and immunosuppression in hepatocellular carcinoma: Insights from single-cell transcriptomics

Highlights • Single-cell landscape:High-resolution mapping of 52,384 cells uncovers hierarchical intra-tumor heterogeneity in HCC.• Key molecule discovery:TMEM176B is identified as the link between tumor malignancy hierarchy and immune remodeling.• Poor prognosis marker: TMEM176B low expression correlates with reduced overall survival (p = 0.021).• Functional validation: TMEM176B overexpression inhibits tumor growth; positively correlates with CXCL9/10 and PD-L1/CTLA-4.

Hong Chen, Jian-Feng Gong, De-Ying He et al. · Translational Oncology · 0 citations

Review Open access 2026

From Tumor Biology to Clinical Perspectives: Novel Biomarkers and Therapeutic Insights in Gastric Cancer

Recent advances ranging from aberrant genetic and epigenetic alterations; dysregulation of oncogenic signaling pathways; sophisticated crosstalk within the tumor microenvironment; intricate microbiota-inflammation interactions; fundamental discoveries to potential clinical translation; and emerging therapeutic strategies for GC are summarized.

Xiya Cheng, Yunshu Ma, Jinglu Yan et al. · Oncology Research · 0 citations