Author

Xiao-Gang Liu

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Open access Aug 2026

A general strategy towards multicolour fluorogenic peptides for wash-free bioassays.

Peptide-based fluorescent probes are valuable tools for live-cell imaging, but conventional labelling approaches often require washing or long incubation, limiting their signal-to-noise ratios. Fluorogenic amino acids (FgAAs) can overcome these limitations, yet their rational design remains challenging owing to the lac...

M. Wong, Lorena Mendive-Tapia, Utsa Karmakar et al. · Nature Chemistry · 0 citations

#quantum computing Oct 2025

Precision Design of Fluorogenic Probes via Orthogonal Tuning of Binding and Photophysics for Isoform-Selective ALDH2 Imaging.

A5 is developed, a fluorogenic substrate for aldehyde dehydrogenase 2 (ALDH2) that exhibits high isoform selectivity and a >240-fold signal enhancement over the standard NADH assay, and enables quantitative imaging of ALDH2 activity across multiple biological scales.

Rongrong Tao, Yu Chen, Taorui Yang et al. · Journal of the American Chem... · 4 citations