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Author

Wei Zhang

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Sep 2026

Discovery of Pyrimidinedione Derivatives Containing Oxime Ester/Carbamate Fragments as Potent Protoporphyrinogen IX Oxidase Inhibitors

To continue our research on developing PPO inhibitors, we replaced the triazinone core of compounds B, G, and H from our previous work with pyrimidinediones, employing a scaffold-hopping strategy to design and synthesize compounds I, J, and K. Compound I18 exhibited potent NtPPO inhibition (Ki = 10.9 nM) and broad-sp...

Wei Zhang, Ke-Shi Luo, Di Li et al. · 0 citations
Sep 2026

Discovery of Novel N -Phenylpyrazole Derivatives as Protoporphyrinogen IX Oxidase Inhibitors

Protoporphyrinogen oxidase (PPO) is one of the major targets for herbicide discovery. N-Phenylpyrazole derivatives bearing ester, oxime, and isoxazoline moieties were synthesized via isomerization, derivatization and cyclization. Bioassays showed C34 potently inhibited Nicotiana tabacum PPO (NtPPO) (Ki = 15.6 nM), wi...

Jia-Hui Zhang, Wei Zhang, Xian-Ying Tang et al. · 0 citations
Aug 2026

Structure-Based Rational Design and Synthesis of Pyridazinone Herbicides Targeting Phytoene Desaturase.

The application of herbicides plays a critical role in ensuring food security. However, the long-term overuse of herbicides can lead to a range of adverse effects. Therefore, it is essential to develop innovative and sustainable herbicides. A series of pyridazinone derivatives targeting phytoene desaturase (PDS) were d...

Chao Chen, Yan Li, Wei Zhang et al. · 0 citations
Aug 2026

Novel N-Phenylphthalimide Derivatives as Protoporphyrinogen IX Oxidase-Targeted Inhibitor Herbicides.

The use of herbicides represents one of the effective weed management strategies. To create high-efficiency, low-risk protoporphyrinogen IX oxidase (PPO)-targeted herbicides, a set of novel N-phenylphthalimides bearing 1,3,4-oxadiazole and acylhydrazide fragments was designed and synthesized. Bioassays revealed that mo...

Wang Geng, Yan Li, Wei Zhang et al. · 0 citations

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