Wayne G. Brisbane

177Lu-Prostate-specific Membrane Antigen Prior to Stereotactic Ablative Radiotherapy in Oligorecurrent Prostate Cancer: Secondary and Exploratory End Point Results from the Randomized Phase 2 LUNAR Trial.

The phase 2 randomized LUNAR trial previously demonstrated that neoadjuvant 177Lu-PNT2002 before stereotactic body radiotherapy (SBRT) significantly improved progression-free survival (PFS) in patients with oligorecurrent hormone-sensitive prostate cancer (orHSPC). We report updated efficacy and safety outcomes with ex...

MUSegNet: Automated detection of clinically significant prostate cancer on micro-ultrasound.

Data-Efficient Prostate Micro-Ultrasound Image Analysis using a Modality-specific Foundation Model

Background and Objective: Micro-ultrasound (MicroUS) is an emerging high-resolution imaging modality for prostate cancer diagnosis and real-time biopsy guidance, but its automated analysis is limited by labor-intensive expert annotation. We aimed to develop and evaluate a foundation model for data-efficient MicroUS ima...

Micro-ultrasound super-resolution with geometry-driven consistency models.

Prostate cancer diagnosis typically relies on image-guided biopsy. Micro-ultrasound (MicroUS) has recently emerged as a promising imaging modality, offering high spatial resolution with comparable diagnostic performance to multi-parametric MRI (mpMRI) at a lower cost. However, unlike MRI, MicroUS volumes are acquired i...