W. Zaman

Microplastics, Nanoplastics, and the Cardiovascular Exposome: Emerging Evidence for Vascular Deposition, Thrombotic Pathways, and Cardiovascular Risk

Microplastics and nanoplastics (MNPs) are increasingly detected in human biological matrices, including blood and cardiovascular tissues, but their causal contribution to cardiovascular disease remains unresolved. This narrative review draws on literature identified through PubMed/MEDLINE and Europe PMC, supplement...

Calcium licenses lipid droplets for ferroptosis: A PKCβ-ACSL4-ALOX15 phosphorylation relay.

Ferroptosis is executed by iron-dependent phospholipid peroxidation, yet the upstream signals that determine when oxidizable lipid pools become lethal remain incompletely resolved. Recent work identifies a calcium-dependent protein kinase C beta (PKCβ) pathway that phosphorylates acyl-CoA synthetase long-chain family m...

Root-Zone Engineering in Closed Soilless Horticulture: From Plant Physiology to Sensor-Guided Control

Soilless systems are increasingly important in protected horticulture because they improve water and nutrient-use efficiency, support year-round production, and reduce dependence on field conditions. However, the root zone is still commonly managed as a passive nutrient reservoir using mainly electrical conductivity an...

Protein–RNA control networks at the plant–pathogen interface

Causal Validation of Mobile RNA and Extracellular Vesicle Signals in Plants: Experimental Frameworks for Sequential Stress Acclimation.

Long-distance molecular transport contributes to coordination between locally stressed tissues and distal organs, but assigning causal systemic-signaling functions to mobile RNAs and extracellular vesicle (EV)-associated molecules remains experimentally challenging. This review critically evaluates the evidence require...

Single-cell and spatial transcriptomics inform mechanistic physiology in non-model animals

This review provides a physiology-centered blueprint for applying single-cell RNA sequencing, single-nucleus RNA sequencing, and spatial transcriptomics to non-model species and critically evaluates dissociation and preservation bias, genome annotation, seasonal and ecological variation, biological replication, pseudor...

Rapid Whole-Plant Signalling Under Compound Environmental Stresses: Systemic Integration, Stomatal Coordination and Stress Memory.

This review develops a mechanistic framework for rapid whole-plant stress signalling under compound environmental stresses and outlines an experimental pipeline combining live biosensors, electrophysiology, vascular imaging, spatial omics, perturbation genetics and crop phenotyping.

Cross-stress memory in plants: mobile RNAs, extracellular vesicles, and local-to-systemic signal integration

This review proposes that cross-stress memory should be reconsidered as a systemic signaling phenomenon, in which local stress encounters generate transmissible molecular information that reshapes distal tissue responsiveness and influences later reactions to the same or different stresses.

Biotic and abiotic elicitors in plant in vitro culture systems: molecular signalling, metabolic reprogramming, and scalable production of bioactive compounds

By linking molecular signalling with metabolic flux and process engineering, this review identifies the experimental and translational priorities required to convert laboratory-scale elicitation into reliable biofactories for plant bioactive compounds.

Beyond copy number: circulating cell-free mitochondrial DNA Fragmentomics and structural states in liquid biopsy.

A laboratory-medicine framework in which cf-mtDNA is considered a multidimensional analyte rather than a single abundance variable is developed, and the central implication is that the next phase of cf-mtDNA diagnostics will depend less on measuring more DNA than on measuring the correct molecular fraction with traceab...

Resilient forest remedies: biochemical diversity, health benefits, and conservation of medicinal berries in changing ecosystems.

The need to protect medicinal berry resources while improving their responsible use in food, nutraceutical, and value-added agricultural systems is highlighted by integrating phytochemistry, food functionality, ecological adaptation, and conservation.

Reactive oxygen species in plants: spatiotemporal organization, redox signaling, and stress adaptation

Current understanding of compartment-specific ROS generation, scavenging, sensing, and signal propagation in plants is synthesized here, with particular emphasis on signaling specificity, redox thresholds, and intercompartmental communication.