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Tung Nguyen Thanh Uong

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Open access Sep 2026

Natural Killer Cell‐Derived Extracellular Vesicle Preparations Demonstrate Potent Antitumor Activity Against Human Glioblastoma In Vitro and In Vivo

ABSTRACT Extracellular vesicles (EVs) derived from activated natural killer (NK) cells represent a promising cell‐free immunotherapy for cancer. However, the use of primary expanded human NK cell‐derived EVs (NK‐EVs) for intractable brain tumours is underexplored. Here, we evaluated common EV isolation methods includin...

Huy Phuoc Quang Nguyen, Meesun Yoon, Shin Jung et al. · Journal of Extracellular Bio... · 0 citations

#gene editing Open access Oct 2026

PTPN22 as a novel therapeutic target: a key intracellular checkpoint for NK cell therapy

Abstract Background PTPN22, a protein tyrosine phosphatase (PTP) family member, has recently emerged as an intracellular regulator in adaptive immune cells. However, its function in natural killer (NK) cells remains unclear despite its high expression in innate immune cells. Methods We analyzed single-cell RNA-sequenci...

Tung Nguyen Thanh Uong, Meesun Yoon, Nhat Phuoc Nguong Minh Nguyen et al. · Journal for ImmunoTherapy of... · 0 citations