Author

Tong Wang

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Review Open access Sep 2026

Remodeling of the brain immune microenvironment in Alzheimer’s disease: interactions among microglia, astrocytes, complement, and the neurovascular unit

Current evidence supports a dynamically reconfigured system rather than a uniformly escalating inflammatory response, which should move beyond broad anti-inflammatory approaches to preserve effective pathological clearance within appropriate disease windows, limit maladaptive synaptic injury, and restore glial and neur...

Tong Wang, Lu Wang, Jia-Ning Cao et al. · Frontiers in Immunology · 0 citations

#gene editing Review Open access Aug 2026

Inflammaging and immunosenescence-driven remodeling of the immune microenvironment in osteoarthritis: mechanisms, immune regulation and immune reprogramming

It is highlighted that future OA treatment may gradually shift from symptom-oriented management toward disease-modifying therapy based on the identification of immune endotypes, and further studies are required to validate the underlying molecular mechanisms, evaluate safety, and conduct clinical trials, thereby facili...

Tong Wang, Wei Jiang, Xing-Xu Chen et al. · Frontiers in Immunology · 2 citations