T-cell receptor (TCR) recognition of antigenic peptides presented by human leukocyte antigen (HLA) molecules underpins adaptive immunity and T cell-based immunotherapy. However, the scarcity of complete interaction data and TCR cross-reactivity challenge robust prediction. Here, we present UpTCR, a unified progressiv...
Tian-Xu Lv, Yang Xiao, Li Chen et al.· Nature Communications· 0 citations
It is shown that cellular perturbation atlases can instead become reinforcement-learning environments, where measured gene responses provide computable rewards for biological reasoning, and introduces PertMind, which combines trusted-trajectory supervised initialization with gene-, pathway-, and format-level reinforcem...
Zhen-Chao Tang, Xiao-Gang Xu, Jia-Fei Wu et al.· 0 citations
This work introduces TCRTSdesign, a framework that concurrently generates novel TCR sequences with specific binding capabilities to target pMHC molecules and predicts the full-atom structures of the TCR-pMHC complex, while optimizing their binding affinity.
Yang Xiao, Yu Zhao, Fandi Wu et al.· Proceedings of the 32nd ACM...· 0 citations
Biomolecular binder design for peptides and antibodies requires generating diverse candidates that satisfy stringent three-dimensional geometric constraints while enabling affinity-oriented exploration under strong structural priors. In current generative models, the effective search space for structurally feasible bin...
Zhihua Tian, Jia-Le Zhou, Ru-Bo Wang et al.· Proceedings of the 32nd ACM...· 0 citations
Designing functional T cell receptors (TCRs) for a given peptide presented by MHC (pMHC) is an emerging yet highly challenging problem in computational immunology. While recent approaches have achieved initial progress, they face two major limitations: (1) the lack of structural information from TCR–pMHC complexes in t...
Yang Xiao, Yu Zhao, Fandi Wu et al.· Proceedings of the 32nd ACM...· 0 citations
Branch-JEPA is introduced, which replaces this point-valued transition with a context-weighted finite set of latent successors, and preserves more distinct futures, while full-set scoring improves the quality of the resulting predictive distribution.
Zhi Song, Ximing Xing, Zhenchao Tang et al.· 0 citations
Semantics-Preserving Exploratory Sampling (SPES), which integrates Graph Laplacian Spectral Noise to respect chain connectivity and Conditional Freedom Modulation to dynamically balance exploration with fidelity, enables diversity-enhanced generation without sacrificing geometric validity under the reported structural...
Zhihua Tian, Jiale Zhou, Rubo Wang et al.· Proceedings of the 32nd ACM...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
