Comparative performance of CRISPR epigenome gene activation: a systematic review on potency and temporal dynamics in mammalian models
Epigenome editing refers to the targeted alteration of gene regulatory states without altering the underlying DNA sequence in a heritable or not manner, directly or indirectly. Specifically, CRISPR activation (CRISPRa) is a epigenome editing system based on the activity of a Cas9 that lacks endonuclease activity (dCas9...