Author

Tatsuji Hasegawa

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#gene editing Open access Oct 2026

Rapamycin rescues neuronal hyperexcitability and seizures driven by megalencephaly-causing AKT3 activation

The consistent therapeutic effects of mTOR inhibition across both systems support downstream targeting of the phosphoinositide 3-kinase–AKT–mTOR pathway as a rational therapeutic strategy for AKT3 -related epilepsy.

Yosuke Miyamoto, Takuma Mori, Mitsuru Ishikawa et al. · Orphanet Journal of Rare Dis... · 0 citations

Aug 2026

End-diastolic velocity as a simplified bedside predictor of estimated cerebral perfusion pressure in neonates: A multicentre prospective observational study.

AIM To elucidate the relationship between estimated cerebral perfusion pressure and cerebral blood flow velocities or resistance index in neonates and to identify optimal Doppler cut-off values for predicting estimated cerebral perfusion pressure. METHODS This multicentre study included neonates with arterial lines a...

Masashi Zuiki, Mikito Ohta, Mariko Ishimaru et al. · Brain & development (Tokyo.... · 0 citations