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Author

Tamara Caspary

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Aug 2026

Ciliary ARL13B Drives Cystogenesis in the Kidney via Its GEF Activity.

BACKGROUND Polycystic kidney disease (PKD) is the leading genetic cause of kidney failure, resulting in the accumulation of fluid filled cysts and gross enlargement of the kidney. Mutations in PKD1 or PKD2, which encode ciliary polycystin proteins, are the most common cause of PKD. These proteins function in a cilia-de...

R. V. Van Sciver, Avery Forster, Leslie Lewis et al. · 0 citations
#gene editing Review Open access Oct 2026

Transcriptomics of independent CRISPR-edited cell lines reveal ciliary-specific ARL13B dependent changes

It is demonstrated that ciliary ARL13B is required to maintain normal ciliary composition and gene expression programs and underscores the value of multi-clone, rescue-based experimental designs for robust transcriptomic analyses.

Olivia Morrison, Tamara Caspary · 0 citations

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