p38α MAPK integrates opposing oncogenic APC/β-catenin/TCF and GUCY2C tumor-suppressor axes in colorectal cancer
Introduction Sporadic colorectal cancers (CRCs) form following initiating APC mutations, inducing constitutive β-catenin/TCF signaling. Similarly, the guanylyl cyclase C (GUCY2C) tumor suppressor axis is universally silenced in CRC. While the GUCY2C receptor is retained, loss of its paracrine hormones guanylin (GUCA2A)...
A. Entezari, Adi Caspi, Jasmine R. Alvarez et al.
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