T. Baldeweg

Multi-centre validation of MELD-graph for automated focal cortical dysplasia detection using 7T compared to paired 3T MRI

Background: Software tools can support MRI diagnosis of focal cortical dysplasias (FCDs) - subtle, surgically-treatable lesions that underlie drug-resistant focal epilepsy (DRFE). MELD-graph, a widely used open-source tool combining surface-based morphometry with a convolutional neural network, was developed using 1.5T...

Spectrally-resolved transfer entropy in resting-state SEEG reveals epileptogenic and non-epileptogenic communication in adults and children with refractory epilepsy

Objective. To characterise directed, frequency-resolved communication between seizure onset zone (SOZ) and non-involved zone (NIZ) regions in resting-state stereo-electroencephalography (SEEG) from adults and children with drug-resistant epilepsy (DRE). Approach. We analysed retrospective SEEG from 21 adults and 18 pae...

Diffusion MRI abnormalities localise the epileptogenic zone in paediatric drug-resistant epilepsy

Automated hippocampal sclerosis detection, using AID-HS, shows robust performance across multi-centre paired 7T and 3T MRI

Background: Hippocampal sclerosis (HS) is a common cause of drug-resistant focal epilepsy (DRFE) and amenable to neurosurgical treatment. Detection relies on MRI but can be challenging. 7 Tesla (T) ultra-high field MRI and automated MRI post-processing tools have independently been shown to improve radiological diagnos...