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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Sweta Gupta

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2 papers indexed here

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#graph neural networks Sep 2026

Abstract B002: Computational Discovery of Evolutionary Synthetic Lethality Networks for Personalized Gene Therapy and Small-Molecule Design in Treatment-Resistant Pediatric High-Grade Glioma

An integrative computational framework is developed to reconstruct resistance evolution, identify state-specific therapeutic vulnerabilities, and design personalized gene therapy and blood-brain barrier (BBB)-penetrant small-molecule therapeutics targeting treatment-resistant pediatric glioma.

Shivi Kumar, Philip Moheno, Sweta Gupta · 0 citations
#graph neural networks Sep 2026

Abstract B004: Targeting Transient Cell-State Dependencies in Glioblastoma Through Single-Cell Evolutionary Modeling and Structure-Based Drug Design

Glioblastoma kills within a median of 15 months even after resection, radiotherapy, and temozolomide, largely because tumor cells adapt to therapy through transient drug-tolerant states long before stable genetic resistance takes hold. Most computational drug discovery pipelines are built on static molecular snapshot...

Shivi Kumar, Philip Moheno, Sweta Gupta · 0 citations

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