This review summarizes the current understanding of microbial–polymer interactions, including surface colonization, biofilm-mediated depolymerization, and intracellular uptake of degradation intermediates, and discusses recent developments in enzyme engineering, strain optimization employing the CRISPR method, and synthetic biology approaches improving catabolic efficiency.
This review includes various bacterial and fungal enzymes associated with major stages of microbial plastic degradation, including biodeterioration, biofragmentation, bioassimilation, and mineralization and highlights recent advancements in metagenomics, enzyme engineering, synthetic biology, and multi‐omics approaches that helps in improving the efficiency and large‐scale industrial feasibility of microbial plastic degradation.
The convergence of fungal systems biology with the principles of circular bioeconomy is illustrated and the technological, economic, and regulatory bottlenecks which need to be overcome are pointed out to fully realise the potential of fungi as the biofactories of the future for the sustainable production of energy and materials.
Babita Thakur, Sukhminderjit Kaur, Ranjan Singh et al.· Journal of Pure and Applied...· 0 citations
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