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Author

Simon Fischer

2 papers indexed here

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Review Oct 2026

The historical evolution of CHO cell line development for biologics production: 60 years and still counting.

Chinese Hamster Ovary (CHO) cells have played a central role in the production of therapeutic proteins since their initial isolation in the 1950s. Over the decades, scientific innovations have transformed CHO cells into the powerhouse of the biopharmaceutical industry. From rudimentary culture conditions and random int...

Juergen Fieder, Stefan Schneider, Simon Fischer · 0 citations
#gene editing Open access Oct 2026

Same hydrolase knockouts, different outcomes: CRISPR/Cas9 editing workflow shapes resulting cellular phenotype and transcriptome in CHO

It is demonstrated that genome editing workflows can shape cellular phenotypes independently of intended genetic modifications, highlighting the need to consider engineering strategy as a critical design parameter when targeting non-essential genes.

Linus Weiss, Stefan Schneider, Kerstin Otte et al. · 0 citations

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