INTRODUCTION
RNA viruses rapidly evolve to evade host immunity, posing a significant challenge to conventional vaccines. Natural infection, however, provides a blueprint for broad immunity by training the immune system against a diverse antigenic landscape. This study addresses the problem of creating a vaccine that mi...
Shu-Gang Qin, Yu-Qin Teng, Jin-Xiu Xin et al.· Journal of Advanced Research· 0 citations
This review discusses AI‐guided strategies for material design, targeting, payload optimization, and in vivo delivery, with particular attention to protein corona‐mediated biological identity, microenvironment‐responsive activation, and biodistribution modeling.
Sheng-Bin Liu, Zhi Liu, Hai-Xing Shi et al.· MedComm· 0 citations
A structured translational roadmap is proposed that prioritizes biologically predictive design, fit-for-purpose safety assessment, scalable good manufacturing practice production, early regulatory alignment, and clinically meaningful benefit over unnecessary structural complexity.
Yi Li, Rui Luo, Yuxuan Li et al.· Biomedicine & pharmacotherap...· 1 citation
The integration of computational prediction with programmable genome and RNA engineering may support more precise, adaptable, and clinically translatable mRNA therapeutics.
Haixing Shi, Shengbin Liu, Dan-Ling Dai et al.· MedComm – Biomaterials and A...· 0 citations
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