Sharif Ahmad Naikoo

Resolving Kinase Resistance Landscapes via Antisymmetric Siamese Graph Networks and Co-Folding Ensembles

Acquired clinical resistance to small-molecule kinase inhibitors arising from single-point mutations within the ATP-binding cleft presents a critical challenge in precision oncology. Conventional computational modeling relies either on rigid docking—which overlooks induced structural alterations—or computationally dema...