Open access
Aug 2026
APOBEC3G Splicing Defects in Nonhuman Primate Models Result in Disparate Viral Mutational Profiles Relative to Humans
It is reported that APOBEC3G (A3G), a potent antiviral restriction factor and the major source of genetic variations in HIV, exhibits a widespread mRNA splicing defect in the Cercopithecinae subfamily, which includes the commonly used NHP models.
A. Mendez, Rachael Springman-Rodriguez, Ayub Bokani et al.
· bioRxiv · 0 citations