Author

Sébastien Britton

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Open access Oct 2026

G-quadruplex-binding ligand RHPS4 reduces Plasmodium falciparum mitochondrial DNA level providing a novel antimalarial strategy

ABSTRACT Malaria caused by Plasmodium falciparum remains a major health threat, killing over 600,000 people annually. The spread of resistance to all major antimalarials, including artemisinins, highlights the urgent need for new drugs with distinct mechanisms of action. Here, we show that the G-quadruplex ligand RHPS4...

Mariam Salim, L. Paloque, F. Nardella et al. · Antimicrobial Agents and Che... · 0 citations

#gene editing Open access Sep 2026

Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivation

It is demonstrated that co-inactivation of HSD17B11 followed by PAC selection can be used to rapidly identify efficient guide RNAs targeting a gene of interest and to readily isolate clones inactivated for one or multiple genes.

Bastien Dumais, Madeleine Bossaert, Patrick Seigneur et al. · bioRxiv · 0 citations