Intrinsically disordered protein regions (IDRs) play central roles in cellular processes such as transcriptional regulation, signal transduction, and subcellular localization, yet their functional design remains challenging. Structure-based design methods do not readily apply to IDRs, and existing protein language mode...
J. Liu, Sebastian Ibarraran, Frank Hu et al.· 0 citations
Directed evolution is a powerful and widely used technique for protein engineering, and reducing the cost of iterated experimental observations has become a major priority for practitioners. A number of recent efforts to use machine-learning-based predictors to improve sequence selection have led to remarkable improvem...
Sebastian Ibarraran, Shriram Chennakesavalu, Frank Hu et al.· Journal of Chemical Informat...· 0 citations
STOMP is a powerful, robust multi-objective alignment algorithm that can meaningfully improve post-training in multiple domains and achieves or ties for the highest hypervolumes on 16/18 protein tasks and 5/6 natural language tasks.
Aadyot Bhatnagar, Peter Mørch Groth, Sebastian Ibarraran et al.· arXiv.org· 0 citations
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