Hunter syndrome (mucopolysaccharidosis type II): Molecular mechanisms, CNS biomarkers, and emerging therapeutic strategies.
Hunter syndrome (mucopolysaccharidosis type II, MPS II) is an X-linked lysosomal storage disorder caused by deficiency of iduronate-2-sulfatase (IDS), leading to lysosomal accumulation of glycosaminoglycans (GAGs), dermatan sulfate and heparan sulfate. Although traditionally viewed as an inherited metabolic disease, in...