Open access
Oct 2026
Evolutionary stabilisation of stressful metabolism via integrated biocomputing and essential-gene metabolic locking circuits
The integrated biocomputing and metabolic locking systems not only alleviate production degeneration but also enable non-degenerative adaptation of toxic terpene synthesis, allowing interrogation of evolutionary shifts for further metabolic optimisation.
Ze-Yu Lu, Craig P. Barry, Masahiro Tominaga et al.
· bioRxiv · 0 citations