Author

S. Vagner

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Open access Aug 2026

U1 snRNA blockade regulates DNA repair genes, DNA damage, and cisplatin sensitivity of lung cancer cells

Previous studies revealed a crosstalk between intronic polyadenylation (IPA) and the DNA damage response (DDR). Indeed, genotoxic agents, including radiations and anticancer drugs (e.g., cisplatin that crosslinks DNA), regulate the ratio of IPA to last-exon transcripts in many genes. Conversely, multiple genes involved...

Alexandre Devaux, C. Labbé, S. Vagner et al. · bioRxiv · 0 citations

Open access Sep 2026

Tumor growth going FAR with KRAS FARnesylation-induced phase separation.

RAS at the plasma membrane relay signals from cell-surface receptors to intracellular pathways. In Cell, Wang et al.1 show that farnesylation drives KRAS cytoplasmic condensation, contributing to its maturation. They identify statins as candidates to overcome resistance to KRAS-targeted therapies.

Sidhant Kalia, S. Vagner · Cell Reports · 0 citations