Author

S. Spina

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Open access Sep 2026

Tau‐associated neuronal loss in the intermediate nucleus of the human hypothalamus, a putative VLPO analog, in progressive supranuclear palsy and Alzheimer's disease

Sleep phenotypes differ in progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). The human intermediate nucleus (IntN), a putative ventrolateral preoptic analog, promotes non‐rapid eye movement (NREM) sleep, but its disease‐specific vulnerability is unclear.

Shima Rastegar-Pouyani, Caroline Lew, F. Pereira et al. · Alzheimer's & Dementia · 0 citations

Open access Jul 2026

Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.

It is found that engraftment of wild-type, but not Grn-deficient, human microglia restore brain-wide progranulin levels, normalize microglial transcriptional states, and ameliorate pathological, functional, and behavioral phenotypes associated with progranulin loss.

H. Davtyan, Sarah Naguib, Y. Voskobiynyk et al. · Molecular Neurodegeneration · 0 citations