Author

S. E. Lehnart

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Open access Oct 2026

Wie Herzmuskelzellen Ionenkanäle dynamisch in Nanodomänen organisieren

Super-resolution microscopy is applied on Ca V 1.3 channels in stem-cell derived atrial myocytes to study cluster architectures and dynamics, finding that these channels are mobile inside membrane domains, being loosely clustered in contrast to previous models of dense channel packing.

Tobias Kohl, Roman Tsukanov, S. E. Lehnart · BIOspektrum · 0 citations

Open access Sep 2026

Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice

Background Most mutations causing hypertrophic cardiomyopathy (HCM) affect sarcomeric proteins. Mutations in junctophilin-2 (JPH2) are also implicated, but the underlying mechanisms remain unclear. An A405S variant in JPH2 was identified in a male adolescent patient with interventricular septal (IVS) hypertrophy. The c...

C. Quinn, S. Lahiri, A. Quick et al. · International Journal of Car... · 0 citations