Background Epigenetic mechanisms underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and accelerate translational applications. We leveraged the VA Million Veteran P...
Shuai Yuan, Michael G. Clark, G. Shakt et al.· Circulation· 0 citations
BACKGROUND AND AIMS
Vascular calcification predicts cardiovascular mortality more strongly than traditional risk factors, yet its molecular basis remains poorly understood. The burden is greatest in chronic kidney disease (CKD), where disordered mineral metabolism accelerates arterial mineral deposition.
METHODS
Cros...
Shen Li, Hong-Bo Liu, Su-Jin Lee et al.· European Heart Journal· 0 citations
Background: Thoracic aortic aneurysms enlarge silently and can cause fatal aortic dissection without timely surgical repair, underscoring the need for improved approaches to identify individuals at high risk. Rare pathogenic variants in established heritable thoracic aortic disease (HTAD) genes explain only a subset of...
David R. Murdock, Pu-Jun Guan, Dong-Chuan Guo et al.· medRxiv· 0 citations
P/LP HTAAD gene variants confer a substantial population-level increased risk of TAAD, suggesting that integrating monogenic and polygenic risks has the potential to enhance patient risk stratification and treatment.
J. DePaolo, D. Smelser, Dong-Chuan Guo et al.· European Heart Journal· 0 citations
A multi-population meta-analysis of genome-wide association studies, including 32,470 individuals with and 1,753,462 without bladder cancer, identifies 70 independent risk loci, of which 43 are novel, and uses experimental approaches to uncover how inherited variation influences this risk in the context of smoking.
L. Prokunina-Olsson, O. Flórez-Vargas, Michael G. Levin et al.· Nature Communications· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
