Author

Rui Sang

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#gene editing Open access Oct 2026

A light-responsive lipid nanoparticle platform delivering Cas9 RNP for VEGFA editing suppresses choroidal neovascularisation

This study developed lipid-based nanoparticles to release Cas9/sgRNA ribonucleoprotein (RNP) complexes under light illumination, enabling light-controlled editing of the VEGFA gene, providing a foundation for spatially controlled VEGFA genome editing as a potential therapeutic strategy for VEGFA-driven macular neovascu...

Rui Sang, Xin-Pu Yang, Ewa M. Goldys et al. · bioRxiv · 0 citations

Review Open access Aug 2026

CRISPR technologies for detecting DNA and RNA methylation: Mechanisms, platforms, and translational opportunities

Abstract DNA and RNA methylation are key epigenetic and epitranscriptomic modifications involved in gene regulation, genome stability, RNA metabolism, and disease progression. Aberrant methylation patterns in cell‐free DNA and RNA have emerged as valuable biomarkers for cancer detection, disease monitoring, and therape...

Kai-Xin Chen, Bi-Yao Yang, Rui Sang et al. · Bioengineering & Translation... · 0 citations