Therapeutic upregulation of gene expression in inherited cardiomyopathies from current approaches to future directions.
Rosemary B. Kirk, C. Santiago, Hugh Watkins et al.
· Nature Cardiovascular Resear... · 0 citations
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Open access
Aug 2026
Functional analysis of TTN uORFs reveals context-dependent translational regulation
Findings indicate that uORF-mediated repression of TTN is context-dependent and not recapitulated in a disease-relevant model, which highlights the complex regulation of TTN expression and the importance of validating regulatory elements in their endogenous context.
Rosemary B. Kirk, Alexander J. Sparrow, Marta Moya-Jódar et al.
· Molecular Therapy: Nucleic A... · 1 citation