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Razvan-Adrian Covache-Busuioc

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Open access Oct 2026

Epigenetic Viral Mimicry in Neuroinflammation: Retrotransposons, cGAS–STING and Microglial Hysteresis

Endogenous retroviruses (ERVs), LINE-1 elements, and other endogenously active transposable-element families are now being studied for their role as a potential interface between epigenetic control and innate immunity. Here, we discuss how locus-specific failures in repressive complexes containing ATRX–DAXX–H3.3 and TR...

S. Tudorache, V. Grigorean, A. Dumitru et al. · Medical Science · 0 citations

Open access Sep 2026

Melanoma Intelligence: Explainable AI Reveals Histopathologic Aggressiveness as the Dominant Axis of Lymph-Node Metastasis

Background/Objectives: Lymph-node metastasis remains central to staging, prognosis, surveillance, and treatment planning in malignant melanoma. At present, most statistical models assessing nodal metastatic risk in malignant melanoma consider pathological descriptors, inflammatory markers, metabolic alterations, clinic...

V. Atanasescu, V. Grigorean, R. Tulin et al. · Journal of Clinical Medicine · 0 citations

#gene editing Review Open access Aug 2026

ZBP1 in Neuroinflammation and Neurodegeneration: Z-Nucleic-Acid Sensing, RHIM Signalling and Therapeutic Targeting

Competition with adenosine deaminase acting on RNA 1 (ADAR1), melanoma differentiation-associated protein 5 (MDA5), double-stranded RNA-dependent protein kinase (PKR), the cyclic guanosine monophosphate–adenosine monophosphate–adenosine monophosphate synthase–stimulator of interferon genes (cGAS–STING) pathway, and oth...

Matei Șerban, C. Toader, Razvan-Adrian Covache-Busuioc · International Journal of Mol... · 0 citations