A tale of signalling and chromatin – how GSK3/WNT pathway controls cell fate decision through CHD4 regulation in stem cells
Despite the known importance of WNT signalling in mammalian development and various cancers, its downstream mechanistic effect on chromatin regulation remains less understood. When WNT signalling is activated, Glycogen Synthase Kinase 3 (GSK3) is inhibited, leading to dephosphorylation and nuclear accumulation of β-cat...