Comparative performance of CRISPR epigenome gene activation: a systematic review on potency and temporal dynamics in mammalian models
Epigenome editing refers to the targeted alteration of gene regulatory states without altering the underlying DNA sequence in a heritable or not manner, directly or indirectly. Specifically, CRISPR activation (CRISPRa) is a epigenome editing system based on the activity of a Cas9 that lacks endonuclease activity (dCas9...
Thyago Leal-Calvo, Matheus Melo Fabiano, Rafaela Luiza Costa Franco et al.
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