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Author

R. Weersma

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Review Open access Oct 2026

Antibiotics and outcomes of cancer immunotherapy: An updated meta-analysis and clinical applications.

The gut microbiome is a modifiable determinant of response to immune checkpoint inhibitors (ICI), positioning antibiotic exposure as a critical yet under-recognized risk factor for worse survival outcomes in immuno-oncology. As nearly 30% of ICI-treated patients receive antibiotics and indications of cancer immunothera...

Serena Porcari, L. Bolte, J. Björk et al. · 0 citations
Review Open access Oct 2026

Importance of faecal sample collection in prospective cohort studies to evaluate the effect of the gut microbiome on cancer development.

The gut microbiome has been linked to cancer in many cross-sectional studies. These studies compared individuals with and without cancer, but they do not establish causation. Prospective cohort studies, with faecal samples collected before a cancer diagnosis, will be instrumental in assessing the role of the gut microb...

E. Vogtmann, Caroline Y. Um, S. Zouiouich et al. · 0 citations
Open access Sep 2026

A gut microbiome-derived risk score is associated with future cancer development

Cancer remains a leading cause of morbidity and mortality worldwide, and the incidence of new cancer cases is rising. While established lifestyle factors such as smoking, obesity, and diet contribute to cancer risk, the gut microbiome has emerged as a hallmark of cancer. However, the role of the gut microbiome in cance...

E. Oosterhout, R. S. Leijdesdorff, O. Kambur et al. · 0 citations
Open access Oct 2026

Genome-wide analysis of genetic modifiers of Crohn’s disease and ulcerative colitis risk in response to tobacco smoking

Summary Background Gene-environment interactions (GxE) are fundamental for understanding the mechanisms of human diseases. Tobacco smoking is of particular interest for Inflammatory bowel disease (IBD), as it worsens Crohn’s disease (CD) but protects against ulcerative colitis (UC). Here, we systematically examined the...

Jing-Jing Bai, R. Gacesa, J. Björk et al. · 0 citations
Sep 2026

Gut microbiome alterations predictive of cancer risk

It is shown that people who are diagnosed with cancer after microbiome sampling have microbiome alterations like those found in diagnosed cancer cases, albeit to a lower degree, across the four populations studied, indicating that the microbiome may evolve towards the one found in cancer well before cancer is diagnosed...

G. Vitali, J. Bjork, O. Kambur et al. · 0 citations
Aug 2026

Upadacitinib effectively suppresses IL13RA2 expression in primary human intestinal fibroblasts derived from Crohn's disease tissue.

Results reveal that CD-derived phIFs show marked heterogeneity in basal IL13RA2 expression, which is strongly induced by IL13 and associated with JAK1-STAT6 pathway activation, both of which are effectively suppressed by upadacitinib.

Li Wang, Rui-Bin Wu, S. de Jong et al. · 0 citations

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