Boronic acids are invaluable chemical reagents that enable the synthesis of complex organic molecules and are uniquely leveraged by medicinal chemists to target biological nucleophiles via an electrophilic boron center, thereby functioning as reversible covalent inhibitors. Despite their prevalence, boronic acids remai...
Forrest G. FitzGerald, Jasmin M. Frei, Erika Zhang et al.· RSC Chemical Biology· 0 citations
It is indicated that three polyglycine strands can form a collagen triple helix when flanked by triple‐helical clamps, consistent with the idea that the triple‐helical architecture predates the recruitment of Pro and Hyp, informs the evolutionary origin of collagen, and offers a blunt‐ended, symmetric scaffold for desi...
Wasin Tiarawut, Gabriel Saenz, Jin-Yi Yang et al.· Biopolymers· 0 citations
This work provides a framework for identifying actionable treatment-induced peptide antigens and supports rational combination strategies pairing KRAS/RAS inhibitors with T cell-based immunotherapies, including BiTE, CAR-pMHC, TCR-T, and cancer vaccine approaches.
Wei-Xi Kang, Allison Glynn, Harshabad Singh et al.· Cancer Research· 0 citations
Chemical modifications to RNA play essential roles in regulating structure, stability, and biological function, yet a unifying physicochemical framework for understanding how these structural modifications perturb the underlying electronic landscape and influence intrinsic reactivity remains lacking. Here, we apply den...
Volga Kojasoy, R. T. Raines· Physical Chemistry, Chemical...· 0 citations
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