CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation
CRISPR-Cas12a represents an efficient tool for genome editing in addition to the extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery system for CRISPR-Cas12a remains challenging. Here, we demonstrate a DNA nanoclew (NC)-based carrier for delivery of Cas12a/CRISPR RNA (crRNA) ribonu...
Xingwu Zhou, Jinqiang Wang, Quanyin Hu et al.
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