AI-Guided Multi-Objective Engineering of Glucoamylase Enables Acidification-Free Starch Saccharification
An artificial intelligence-guided strategy to simultaneously improve the thermostability, pH tolerance, and catalytic activity of glucoamylase from Penicillium oxalicum (PoGA) and folding energy guided recombination to achieve simultaneous multi property optimization is developed.
Jie Qiao, Xiao-Rui Ma, Yi-Bo Song et al.
· bioRxiv · 0 citations